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Purine starvation has been identified as a potential novel mechanism underlying IBS with lower fecal hypoxanthine abundance in IBS-C and IBS-D

For patients participating in clinical trials of retatrutide, the trial team will provide detailed rotation guidance as part of the study protocol

Both mechanisms are very different, though both help in appetite management and monitoring glucose

May 30, 2025

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Ongoing Support & Optimization If you begin a supervised weight loss program, your care team may monitor weight trends, appetite, side effects, metabolic markers, adherence, and long-term maintenance planning